MK-801与环境线索交互作用对吗啡行为敏感化的影响

Interactions of MK-801 and Environmental Cues on the Behavioral Sensitization Induced by Morphine

为探讨MK-801与环境线索交互作用对吗啡诱导行为敏感化的影响，将42只大鼠随机分为对照组，MK-801组，吗啡组(匹配和非匹配)和MK-801 + 吗啡组(匹配和非匹配)。行为敏感化模型建立分为发展期，戒断期和表达期三个阶段。实验结果发现：同时给予MK-801(0.1㎎‧㎏-1)会促进吗啡(5㎎‧㎏-1)诱导大鼠行为敏感化的发展，而且会使MK-801成为大鼠行为敏感化表达所必须的条件性刺激。MK-801的内部线索作用过强，从而削弱了环境的外部线索作用。研究结果表明：MK-801对吗啡诱导行为敏感化的影响存在状态依赖(state -dependency)现象，提示在NMDA受体与行为敏感化关系的研究中应考虑选择刺激特性更小的药物。

Many laboratories have reported that co-administration of N-methy1-D-aspartate (NMDA) receptor antagonists such as MK-801 with addictive drugs prevents the development of behavioral sensitization and therefore concluded that NMDA receptor transmission is necessary for sensitization. However， according to “State-dependency” interpretation， NMDA receptor antagonists do not prevent sensitization. Rather， they become a conditioned stimulus for the sensitized response. There is also considerable evid