轻度认知功能障碍患者工作记忆中脑电能量及皮质联络功能的变化特征

Characteristics of EEG Power and Coherence in Patients with Mild Cognitive Impairment during Working Memory Processing

探讨轻度认知功能障碍患者（MCI）工作记忆状态下脑电能量及皮质联络功能的变化特征。被试为从社区选取的35名轻度认知功能障碍患者和34名健康志愿者。采用简单计算回忆方法，结果发现工作记忆加工过程中会引起4.0~18.0Hz范围内功率值的改变，且MCI组高于正常对照组；MCI患者在中央、顶、颞叶的半球间相干系数均显著高于正常对照组。研究结果提示MCI患者可能存在中央、顶、颞叶皮层的功能减退，工作记忆状态下通过代偿机制仍能维持加工的有效性。

The clinical condition characterized by objective memory disturbances in the absence of other cognitive deficits is called mild cognitive impairment (MCI). MCI is one of the risk factors of Alzheimer’s disease (AD). The study of cognitive impairment in patients with MCI， particularly memory deficiency， may aid in obtaining clues of early stage of AD. Many studies have reported that working memory plays an important role in learning， calculating， reasoning， and verb comprehension in cognitive pro