氟暴露所致脑损伤及硒的干预作用

The Study on Brain Impairment from Exposure to Fluoride and the Intervention of Selenium

氟是人体必需的微量元素，但摄入过量能引起骨相系统损害。流行病学和动物实验结果表明，长期过量氟暴露还能损害中枢神经系统，从而损伤动物的学习记忆力和儿童的智商。自由基损伤伤学说可能是氟致脑损伤的机理之一。而硒也是人类必需的微量元素之一，动物实验结果表明，适量硒能拮抗氟致脑功能的损伤，其机理可能与硒的抗氧化性的生物学功能有关。

Fluoride is a trace element which human body need， but it can arouse injure on bone System if one who have taken in too much. Epidemiology and results of animals experiment show that it can lead to impairment of central nervous system when exposure to high doses of fluoride occurs for prolonged period of time， then hazard to in learning and memory of animals and the intelligence quotient of children. The free─radical theory may be an important factor in connection with the mechanism of the brain dysfunction due to chronic fluorosis. Selenium（Se） is an esstential trace element， results of animals experiment provide evidence that proper concentration of Se might antagonize brain impairment caused by fluoride toxicity， its mechanism may be based on the biological function of antioxidant capacity of Se.