中枢胆碱能系统码啡成瘾的影响研究现状

Effect of Central Cholingeric System on Addition of Morphine

介绍了中枢胆能碱能系统对吗啡成瘾的影响及其机制。研究结果表明，吗啡成瘾过程中伏隔核等脑区细胞间乙酰胆碱水平发生了改变；去除伏隔核等脑区胆碱能细胞强化了吗啡成瘾行为；胆碱能激动剂和抑制剂都能干预码啡成瘾、但机制可能不同─前者可能通过与多巴胺能交互作用来实现，后者可能通过干扰记忆或者加速吗啡代谢而发挥作用；胆碱能受体对吗啡成瘾也具有重要影响。

This article reviews the effects of the central cholingic system on the addition of the morphine and the related mechanisms. A considerable amount of research show that morphine induces changes in release of extracellular acetylcholine in the nucleus accumbens（NAc）and other brain areas. It was also reported that cholinergic cell ablation in the Nac or the striatum enhances the addiction of morphine by suing immunotoxin─mediated cell targeting. The cholinergic agonists and antagonists can both interfere with the addiction of morphine but the mechanism may be different. The former probably exerts addiction of morphine through he interaction of the cholinergic system and the dopaminergic system. The latter perhaps works in the way of blocking the memory or accelerating the metabolism of morphine. Cholinergic receptor plays a important role in the addiction of morphine.