心理应激与DNA损害

Psychological Stress and DNA Damage

心理应激不仅能使人的行为特征发生变化，而且也能使人的生理状况发生改变，因此，被认为是某些身心疾病的诱因。在此过程中，DNA损害是心理应激造成的最终结果之一。有关DNA损害，虽然以往的研究者以人或动物为对象进行了一系列急性应激和慢性应激的实验研究，但是，心理应激是如何造成DNA损害的过程还不清楚，具体的生理心理机制还未阐明。该文利用健康心理学提出的理论模型对此进行了分析，阐述了心理应激与DNA损害之间联系的可能的机制，强调了氧化应激难这一过程中的重要作用。同时，为临床制订预防疾病的干预措施提供了思路。

Psychological stress affects human beings not only at behavior levels but also physical levels， which even results in some disease. DNA─damage if one of the ultimate outcomes of those behavior disorders or diseases. However， the mechanism how psychological stress leads to DNA─damage is unclear. This article critically reviews what effects psychological stress has on DAN damage and the possible mechanisms of those effects. Oxidative stress plays an important role in the process of psychological stress leading to DNA damage. With a theoretical model in health psychology being integrated into some experimental research about acute and chronic stress， the relationship between the psychological stress and the DNA─damage has been clarified. Moreover， potential measures of intervention for clinical practice have been proposed to prevent diseases.